![]() ![]() The PK profile can then be evaluated with regards to efficacy and safety, allowing the physician to select the best dose. This can then be used to simulate the subsequent PK profile after administration of a proposed dose. A more advanced method uses pharmacometrics models to estimate the pharmacokinetic (PK) parameters of the given patient, using a Bayesian method based on the collected serum concentrations. It may take a while to find the right dose, resulting in sub-optimal therapy, especially if the patient PK changes during therapy. The TDM approach is often executed in a rudimentary way, simply increasing or decreasing the dose until the desired target is reached. ![]() ![]() The dose for these compounds is determined through Therapeutic Drug Monitoring (TDM), where the serum concentration is measured after administration of the standard dose, and the dose is subsequently increased or decreased in order to reach the target window. As absorption, distribution, metabolization and elimination of drugs differ widely among individuals, it is sometimes not possible to find a single dose that will work in every individual. When administering a drug, it is the desire of the clinician to reach a serum concentration in the patient that is in the target window: both safe (not too high) and efficacious (not too low). ![]()
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